A potential defense mechanism against amyloid deposition in cerebellum

Amyloid-? (A?) is the major component of senile plaques in Alzheimer’s disease (AD) brains. Senile are generally observed cerebral cortex (CTX) rather than cerebellum (CBL) AD patients. However, it not clear why CBL has less A? deposition CTX. It very important to elucidate mechanism suppressing CBL, because contributes understanding only pathogenesis but also prevention and cure AD. In this study, we explored figure out potential reducing CBL. We higher age-dependent elevation level CTX human APP knock-in model mice, although detected no significant differences levels interstitial fluid these brain tissues. These data imply that due enhanced clearance altered production To gain insights into injected fluorescence-labeled Importantly diffusion area fluorescent was roughly six-times larger within 2 h injection. addition, decreased sharply after 24 CBL-injected robustly deep cervical lymph nodes (DcLNs). contrast, consistent up 72 CTX-injected faintly DcLNs. Our suggest drainage association with meningeal lymphatic system responsible for